|Application ||WB, IHC-P, E|
|Calculated MW||57825 Da|
|Immunogen||Recombinant human CD54.|
|Shelf Life||18 months from the date of despatch|
|Other Names||Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, CD54, ICAM1|
|Target/Specificity||Rabbit anti Human CD54 antibody recognizes human CD54, otherwise known as Intercellular adhesion molecule 1 or ICAM-1. CD54 is a 532 amino acid single pass type I membrane glycoprotein containing five Ig-like C2-type domains. CD54 is widely expressed and acts as a ligand for the leukocyte integrin LFA-1 (CD11a/CD18) and Mac-1 integrins, it is the major receptor for human rhinovirus(Stauntonet al.1989).CD54 is highly expressed on activated endothelial cells (Favoloro 1993) and plays a role in transendothelial cell migration to sites of acute inflammation, functioning primarily as an adhesion molecule between endothelial cells and leucocytes, following injury or stress (Manes and Pober 2011). Levels of soluble CD54 in serum (Matalliotakiset al.2001) or urine (Kimet al.2006), can be potentially used as an indication of infection, inflammation and certain tumour, and as a target for immunosuppression in transplantation.|
|Preservative & Stabilisers||None present|
|Storage||Prior to reconstitution store at +4℃.After reconstitution store at -20℃.|
|Precautions||Anti Human CD54 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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