|Application ||WB, IHC-P, FC|
|Calculated MW||154793 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Purified human placental IGF-I receptor.|
|Shelf Life||18 months from the date of despatch|
|Other Names||Insulin-like growth factor 1 receptor, 188.8.131.52, Insulin-like growth factor I receptor, IGF-I receptor, CD221, Insulin-like growth factor 1 receptor alpha chain, Insulin-like growth factor 1 receptor beta chain, IGF1R|
|Target/Specificity||Mouse anti Human CD221 antibody, clone 1H7 recognizes human CD221, a ~155 kDa receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by western blotting (Liet al.1993).CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221 (Liet al.1993).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4oC or at -20oC if preferred.|
|Precautions||Anti Human CD221 Antibody, clone 1H7 is for research use only and not for use in diagnostic or therapeutic procedures.|
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