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Anti Human CD221 Antibody, clone 1H7

Mouse Anti-Human Monoclonal Antibody

     
  • FC - Anti Human CD221 Antibody, clone 1H7  ABD13412
    Staining of human peripheral blood granulocytes with Mouse anti Human CD221
  • FC - Anti Human CD221 Antibody, clone 1H7  ABD13412
    Staining of human peripheral blood granulocytes with Mouse anti Human CD221: Alexa Fluor® 488
  • FC - Anti Human CD221 Antibody, clone 1H7  ABD13412
    Staining of human peripheral blood granulocytes with Mouse anti Human CD221: Low Endotoxin
  • FC - Anti Human CD221 Antibody, clone 1H7  ABD13412
    Staining of human peripheral blood granulocytes with Mouse anti Human CD221: RPE
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC
Primary Accession P08069
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 1H7
Calculated MW 154793 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Purified human placental IGF-I receptor.
Shelf Life 18 months from the date of despatch
Gene ID 3480
Other Names Insulin-like growth factor 1 receptor, 2.7.10.1, Insulin-like growth factor I receptor, IGF-I receptor, CD221, Insulin-like growth factor 1 receptor alpha chain, Insulin-like growth factor 1 receptor beta chain, IGF1R
Target/Specificity Mouse anti Human CD221 antibody, clone 1H7 recognizes human CD221, a ~155 kDa receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognizes an epitope in the alpha subunits of CD221, demonstrated by western blotting (Liet al.1993).CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partially block binding of IGF-I and IGF-II to CD221 (Liet al.1993).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4oC or at -20oC if preferred.
PrecautionsAnti Human CD221 Antibody, clone 1H7 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13412
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