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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti Human MICA/Micb Antibody, clone 6D4    

Anti Human MICA/Micb Antibody, clone 6D4

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q29980
Other Accession Q29983
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 6D4
Calculated MW 42646 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen MICA transfected C1R cells.
Shelf Life 18 months from the date of despatch
Gene ID 4277
Other Names MHC class I polypeptide-related sequence B, MIC-B, MICB {ECO:0000312|EMBL:CAA62823.1}
Target/Specificity Mouse anti Human MICA/Micb antibody, clone 6D4 recognizes nonclassical MHC class I chain A (MICA) and nonclassical MHC class I chain MICB (MICB). MICA and MICB are stress inducible antigens, which are closely related and appear functionally indistinguishable. MICA and MICB are ligands for NKG2D, an activating receptor on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. MICA is principally expressed on intestinal epithelium, and several epithelial tumours. Expression may be induced to high surface levels by heat shock, oxidative stress, and virus infection. Clone 6D4 is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells (Jinushiet al.2003).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4oC or at -20oC if preferred.
PrecautionsAnti Human MICA/Micb Antibody, clone 6D4 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13420
(40 western blots)
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