|Application ||IHC-F, FC|
|Calculated MW||31842 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||PD-1 transfected BHK cells|
|Shelf Life||18 months from date of despatch.|
|Other Names||Programmed cell death protein 1, Protein PD-1, mPD-1, CD279, Pdcd1, Pd1|
|Target/Specificity||Rat anti Mouse CD279 antibody, clone RMP1-14 recognizes mouse CD279, a 55kD cell surface protein which is a member of the CD28/CTLA-4 family, otherwise known as programmed death-1 (PD-1). CD279 is expressed predominantly on activated T- and B- lymphocytes and on a subset of thymocytes. Studies suggest that CD279, an immunoinhibitory receptor, plays a critical role in peripheral tolerance induction and prevention of autoimmune disease. Two members of the B7 family, B7-H1 (PD-L1) and B7-DC (PD-L2), have been identified as the ligands for CD279. Antibodies produced by clone RMP1-14 have been reported to block the binding of both B7-H1-Ig and B7-DC-Ig fusion proteins to PD-1 transfected BHK cells (Yamazakiet al.2005).|
|Preservative & Stabilisers||0.09%Sodium Azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Mouse CD279 Antibody, clone RMP1-14 is for research use only and not for use in diagnostic or therapeutic procedures.|
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