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Anti Human Caspase-2 Antibody, clone 1C10

Mouse Anti-Human Monoclonal Antibody

  • WB - Anti Human Caspase-2 Antibody, clone 1C10  ABD13442
    Western Blot analysis of caspase-2 expression in Ramos and Jurkat cell lines using Mouse anti Human Caspase-2
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42574
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 1C10
Calculated MW 31608 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Recombinant human caspase-2 (amino acids 32-169) purified from E.coli.
Shelf Life 18 months from date of despatch.
Gene ID 836
Other Names Caspase-3, CASP-3,, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, CASP3, CPP32
Target/Specificity Mouse anti Human caspase-2, clone 1C10 recognizes human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family. Caspase-2, also known as Neural precursor cell expressed developmentally down-regulated protein 2 (NEDD2) is required for permeabilisation of mitochondria and resulting amplification of caspase activity in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to release of cytochrome c and Smac from mitochondria and translocation of Bax from the cytoplasm to the mitochondria and ultimately cell disassembly.In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Caspase-2 Antibody, clone 1C10 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13442
(40 western blots)
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