|Application ||WB, E|
|Calculated MW||31608 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Recombinant human caspase-2 (amino acids 32-169) purified from E.coli.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Caspase-3, CASP-3, 220.127.116.11, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3 subunit p17, Caspase-3 subunit p12, CASP3, CPP32|
|Target/Specificity||Mouse anti Human caspase-2, clone 1C10 recognizes human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family. Caspase-2, also known as Neural precursor cell expressed developmentally down-regulated protein 2 (NEDD2) is required for permeabilisation of mitochondria and resulting amplification of caspase activity in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to release of cytochrome c and Smac from mitochondria and translocation of Bax from the cytoplasm to the mitochondria and ultimately cell disassembly.In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Caspase-2 Antibody, clone 1C10 is for research use only and not for use in diagnostic or therapeutic procedures.|
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