|Application ||IHC-F, E, Func|
|Calculated MW||51276 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Native purified factor P from human serum.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Properdin, Complement factor P, CFP, PFC|
|Target/Specificity||Mouse anti Human Factor P antibody, clone 10-18 recognizes human factor P, a 53 kDa glycosylated protein present in blood serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections.Mouse anti Human Factor P antibody, clone 10-18 is reported to inhibit the function of factor P. Removal of Sodium Azide is recommended prior to use in functional assays. AbD Serotec recommend the use of EQU003 for this purpose.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Factor P Antibody, clone 10-18 is for research use only and not for use in diagnostic or therapeutic procedures.|
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