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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti Human CD279 Antibody, clone MIH4    

Anti Human CD279 Antibody, clone MIH4

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti Human CD279 Antibody, clone MIH4  ABD13451
    Staining of human peripheral blood monocytes with Mouse anti Human CD279:RPE
  • FC - Anti Human CD279 Antibody, clone MIH4  ABD13451
    Staining of human peripheral blood monocytes with Mouse anti Human CD279:A488
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15116
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MIH4
Calculated MW 31647 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Human CD279 - transfected L cells.
Shelf Life 18 months from date of despatch.
Gene ID 5133
Other Names Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1
Target/Specificity Mouse anti Human CD279 antibody, clone MIH4 detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1). CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation.Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human CD279 Antibody, clone MIH4 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13451
(40 western blots)
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