|Application ||WB, IHC-F, IP|
|Calculated MW||52668 Da|
|Shelf Life||18 months from date of despatch.|
|Other Names||Presenilin-1, PS-1, 3.4.23.-, Protein S182, Presenilin-1 NTF subunit, Presenilin-1 CTF subunit, Presenilin-1 CTF12, PS1-CTF12, PSEN1, AD3, PS1, PSNL1|
|Target/Specificity||ABD13499 recognises presenilin-1 (PSEN1), an integral membrane protein that is widely expressed, especially in brain tissue.PSEN1 is an essential component of the gamma-secretase complex, along with APH-1 (APH-1A or APH-1B), PSEN2, Pen-2 (PEN2), and nicastrin (NCSTN). This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes. Mutations of presenilin-1 are associated with early onset Alzheimer's disease.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Presenilin-1 (Loop) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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