|Application ||WB, IHC-P, IHC-F, IP|
|Calculated MW||84601 Da|
|Immunogen||Synthetic peptide corresponding to a region of human MLH1 encoded within exon 20.|
|Shelf Life||18 months from date of despatch.|
|Other Names||DNA mismatch repair protein Mlh1, MutL protein homolog 1, MLH1, COCA2|
|Target/Specificity||Rabbit anti Human MLH1 antibody recognizes human MLH1 (Homologue 1 of E. coli MutL Protein). MLH1 is housekeeping gene, which plays an important role in DNA mismatch repair. In humans, the protein encoded by MLH1 forms at least two dimeric factors with either PMS2 or MLH3. These heterodimers are reported to form larger complexes made up of several other DNA repair proteins, including MSH2 and MSH6. In addition to DNA mismatch repair, MLH1 is thought to pay a role in the induction of apoptosis in response to DNA damage. Mutations in MLH1 have been implicated in certain types of colon cancer (Bronneret al.1994).|
|Preservative & Stabilisers||0.09%Sodium Azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human MLH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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