|Application ||WB, IHC-P, E, IP|
|Calculated MW||56044 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Histidine-tagged recombinant peptide corresponding to amino acids 176-240 of human IRF5, purified from E. coli.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interferon regulatory factor 5, IRF-5, IRF5|
|Target/Specificity||Mouse anti Human IRF5, clone 10T1 recognises human interferon regulatory factor 5 (IRF5), a 58kDa member of the IRF family which acts as a key regulator of interferon gene transcription, and is expressed in B cells and dendritic cells, and is inducible by type I interferon (IFN) in most lymphoid cells.The role of IRF3 and IRF7 as transcriptional mediators of virus- and IFN-induced signaling pathways is well documented. Studies have shown that IRF5 can also regulate IFN gene transcription, but appears to be more restricted in its cellular expression and range of viral stimuli, and has the ability to induce a wide range of chemokines involved in T-lymphocyte recruitment, including RANTES, MCP-1 and IP-10 (Barneset al.2002).|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human IRF5 Antibody, clone 10T1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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