|Application ||WB, E|
|Calculated MW||120922 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Recombinant human TLR7 (amino acids 451-500) purified from Escherichia coli.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Toll-like receptor 7, TLR7|
|Target/Specificity||Mouse anti Human TLR7, clone 4F4 recognizes human TLR7 (toll-like receptor 7), a 121 kDa type I transmembrane protein belonging to the toll-like receptor (TLR) family. TLR7is predominantly expressed in the spleen, lung and placenta (Chuanget al.2000).TLRs are highly conserved proteins which play a key role in activation of innate immunity, through the recognition of distinct molecular patterns expressed by infectious agents. TLR7 recognizes and interacts with single-stranded RNA (ssRNA) derived from viruses such as influenza , HIV-1 (human immunodeficiency virus type I) and Sendai, and some siRNAs, resulting in the activation of the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway, and the production of proinflammatory signaling molecules (Dieboldet al.2004)|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human TLR7 Antibody, clone 4F4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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