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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti Human LOX-1 (soluble) Antibody, clone LOX19-22    

Anti Human LOX-1 (soluble) Antibody, clone LOX19-22

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78380
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names LOX19-22
Calculated MW 30959 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatantPurified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Recombinant soluble LOX-1 expressed in E.coli.
Shelf Life 18 months from date of despatch.
Gene ID 4973
Other Names Oxidized low-density lipoprotein receptor 1, Ox-LDL receptor 1, C-type lectin domain family 8 member A, Lectin-like oxidized LDL receptor 1, LOX-1, Lectin-like oxLDL receptor 1, hLOX-1, Lectin-type oxidized LDL receptor 1, Oxidized low-density lipoprotein receptor 1, soluble form, OLR1, CLEC8A, LOX1
Target/Specificity Mouse anti Human LOX-1 (Soluble) antibody, clone LOX19-22 recognizes the lectin-like oxidised low-density lipoprotein (LDL) receptor (LOX-1), a 31kDa protein of the C-type lectin superfamily. This receptor mediates the recognition, internalisation and degradation of oxidised LDL. It is a Type II membrane protein with a typical C-type lectin structure at the extracellular C-terminus which recognizes the ligand. LOX-1 activation by oxidised LDL causes endothelial changes such as decreased nitric oxide release and an increased expression of adhesion molecules. LOX-1 also binds activated platelets and apoptotic cells. The expression of LOX-1 is induced by proatherogenic conditions such as hyperlipidemia, hypertension and diabetes and as such appears to contribute to the pathogenesis of vascular disorders, particularly atherosclerosis. It can be cleaved by an unknown protease at the extracellular juxtamembrane region to release the soluble form (aa58-273) of LOX-1, recognized by Mouse anti Human LOX-1 (Soluble) antibody, clone LOX19-22.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human LOX-1 (soluble) Antibody, clone LOX19-22 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13523
(40 western blots)
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