|Application ||WB, E|
|Calculated MW||18403 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Human slow skeletal troponin C|
|Shelf Life||18 months from date of despatch.|
|Other Names||Troponin C, slow skeletal and cardiac muscles, TN-C, TNNC1, TNNC|
|Target/Specificity||Mouse anti Human Troponin C antibody, clone 1A2 recognizes human Troponin C, an 18kDa subunit of the Troponin complex found on actin filaments in muscle tissue. Troponin C (TnC) is responsible for binding calcium ions. In the absence of calcium, TnC has an inhibitory action on the actin filaments. When calcium binds to TnC, a conformational change takes place in Troponin I, which in turn causes a change in another associated protein, tropomyosin. Troponin and tropomyosin is repositioned away from the actin filaments, leaving the myosin binding sites available for cross-bridges to form and muscle contraction to occur. Mouse anti Human Troponin C antibody, clone 1A2 recognizes free cardiac Troponin C and TnC in binary complex with cardiac Troponin I. The antibody does not recognize free cardiac Troponin I or cardiac Troponin T.|
|Preservative & Stabilisers||0.09%Sodium Azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Troponin C Antibody, clone 1A2 is for research use only and not for use in diagnostic or therapeutic procedures.|
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