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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti Human Troponin I (Cardiac/Phosphorylated) Antibody, clone 1G11    

Anti Human Troponin I (Cardiac/Phosphorylated) Antibody, clone 1G11

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P19429
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 1G11
Calculated MW 24008 Da
Additional Information
Other Species Rat,Cat,B,Dog,Ga,Pig
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Phosphorylated form of human cardiac Troponin I.
Shelf Life 18 months from date of despatch.
Gene ID 7137
Other Names Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1
Target/Specificity Mouse anti Human Troponin I (Cardiac/Phosphorylated) antibody, clone 1G11 recognizes the phosphorylated form of human cardiac Troponin I (cTnI). Troponin I is a 24kDa subunit of Troponin, a protein found on muscle tissue responsible for muscle contraction. When calcium binds to Troponin C, a conformational change moves Troponin I and tropomyosin out of the way of the myosin binding sites on the actin filaments in muscles. This allows cross-bridging to occur and the muscle to contract. Levels of cTnI in serum are commonly used as a marker for cardiac cell damage and death. Phosphorylation of cTnI results in changes in the activity and function of Troponin. One possible form of phosphorylation is by Protein kinase A. Protein kinase A phosphorylation of serine 22 and serine 23 reduces calcium sensitivity of Troponin and leads to an acceleration in relaxation. Changes in cTnI phosphorylation have been reported in failing hearts. Mouse anti Human Troponin I (Cardiac/Phosphorylated) antibody, clone 1G11 recognizes free cTnI and cTnI in complex with other Troponin components. It does not cross-react with skeletal Troponin I.
Preservative & Stabilisers 0.09%Sodium Azide
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Troponin I (Cardiac/Phosphorylated) Antibody, clone 1G11 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13527
(40 western blots)
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