|Application ||IHC-F, FC, IP, Func|
|Calculated MW||50495 Da|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, Tumor necrosis factor receptor superfamily member 1A, membrane form, Tumor necrosis factor-binding protein 1, TBPI, TNFRSF1A, TNFAR, TNFR1|
|Target/Specificity||Mouse anti Human CD120a antibody, clone H398 recognizes both the 60 kDa cell surface and soluble fragment of human CD120a, otherwise known as TNF receptor type I (TNFR1/sTNFR1), a ubiquitously expressed transmembrane glycoprotein and member of the tumour necrosis factor receptor (TNFR) superfamily, which plays a key role in regulating the inflammatory response, acting as a receptor for tumour necrosis factor alpha (TNF-alpha) and lymphotoxin-alpha (TNF-beta). CD120a also plays a role in apoptosis, cytokine induction, cell differentiation, tumour necrosis and early stages of graft-versus-host disease, and its soluble form sTNFR1, acts as an inhibitor of TNF-alpha induced responses by acting as a decoy receptor. Mouse anti Human CD120a antibody, clone H398 completely inhibits functional activity via CD120a by inhibiting receptor signalling, but does not always inhibit ligand binding of TNF. Mouse anti Human CD120a antibody, clone H398 has been used successfully in functional studies on U937, K562, Colo 205, YT, MCF-7, HeLa and L929 cells (Thomaet al.1990)..|
|Preservative & Stabilisers||None present|
|Storage||Store at -20℃ only.|
|Precautions||Anti Human CD120a Antibody, clone H398 is for research use only and not for use in diagnostic or therapeutic procedures.|
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