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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-PRKAR1A Picoband Antibody   

Anti-PRKAR1A Picoband Antibody

     
  • WB - Anti-PRKAR1A Picoband Antibody ABO10102
    Western blot analysis of PRKAR1A expression in rat thymus extract (lane 1), HEPG-2 whole cell lysates (lane 2) and MCF-7 whole cell lysates (lane 3). PRKAR1A at 48KD was detected using rabbit anti- PRKAR1A Antigen Affinity purified polyclonal antibody (Catalog #ABO10102) at 0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method .
  • IHC - Anti-PRKAR1A Picoband Antibody ABO10102
    PRKAR1A was detected in paraffin-embedded sections of rat testis tissues using rabbit anti- PRKAR1A Antigen Affinity purified polyclonal antibody (Catalog # ABO10102) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
  • IHC - Anti-PRKAR1A Picoband Antibody ABO10102
    PRKAR1A was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- PRKAR1A Antigen Affinity purified polyclonal antibody (Catalog # ABO10102) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
  • IHC - Anti-PRKAR1A Picoband Antibody ABO10102
    PRKAR1A was detected in paraffin-embedded sections of human lung cancer tissues using rabbit anti- PRKAR1A Antigen Affinity purified polyclonal antibody (Catalog # ABO10102) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P10644
Host Rabbit
Reactivity Human, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for cAMP-dependent protein kinase type I-alpha regulatory subunit(PRKAR1A) detection. Tested with WB, IHC-P in Human;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 5573
Other Names cAMP-dependent protein kinase type I-alpha regulatory subunit, Tissue-specific extinguisher 1, TSE1, cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed, PRKAR1A, PKR1, PRKAR1, TSE1
Calculated MW 42982 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, By Heat

Western blot, 0.1-0.5 µg/ml, Human, Rat
Subcellular Localization Cell membrane .
Tissue Specificity Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Protein Name cAMP-dependent protein kinase type I-alpha regulatory subunit
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen E.coli-derived human PRKAR1A recombinant protein (Position: E2-E81). Human PRKAR1A shares 89.9% and 92.4% amino acid (aa) sequence identity with mouse and rat PRKAR1A, respectively.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name PRKAR1A
Synonyms PKR1, PRKAR1, TSE1
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Cellular Location Cell membrane.
Tissue Location Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible
Research Areas
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Background

cAMP-dependent protein kinase type I-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR1A gene. This protein encoded by this gene was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

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$ 280.00
Cat# ABO10102
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