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Anti-Phosphoserine Antibody (Monoclonal, PSR-45)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q5M819 |
| Host | Mouse |
| Isotype | Mouse IgG1 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Phosphoserine detection. Tested with WB in Human; all kinds of animals.No cross reactivity with otherproteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 304429 |
|---|---|
| Other Names | Phosphoserine phosphatase, PSP, PSPase, 3.1.3.3, O-phosphoserine phosphohydrolase, Psph |
| Calculated MW | 24968 MW KDa |
| Application Details | Western blot, 1-2 µg/ml, Human, all kinds of animals |
| Tissue Specificity | PSAT1: Expressed at high levels in the brain, liver,kidney and pancreas, and very weakly expressed in the thymus,prostate, testis and colon. |
| Protein Name | Phosphoserine phosphatase |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | PSR-45 |
| Immunogen | Phosphoserine conjugated to Keyhole Limpet Hemocyanin(KLH). |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Name | Psph {ECO:0000312|RGD:1308764} |
|---|---|
| Function | Catalyzes the last irreversible step in the biosynthesis of L-serine from carbohydrates, the dephosphorylation of O-phospho-L- serine to L-serine. L-serine can then be used in protein synthesis, to produce other amino acids, in nucleotide metabolism or in glutathione synthesis, or can be racemized to D-serine, a neuromodulator. May also act on O-phospho-D-serine. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P78330} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Phosphoserine phosphatase fills an important role in the biosynthesis of serine from carbohydrates by catalyzing the last step, hydrolysis of O-phosphoserine. Phosphoserine phosphatase activity in lymphoblasts and fibroblasts was reduced to 25% of normal values. The human phosphoserine gene(PSP)is mapped to the pter-q22 region of chromosome 7.
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