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Anti-Tryptophan Hydroxylase Antibody (Monoclonal, WH-3)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8CGU9 |
| Host | Mouse |
| Isotype | Mouse IgG3 |
| Reactivity | Human, Rat |
| Clonality | Monoclonal |
| Format | Lyophilized |
| Description | Mouse IgG monoclonal antibody for Tryptophan Hydroxylase, tryptophan hydroxylase 1; tryptophan hydroxylase 2 (TPH1; TPH2) detection. Tested with WB in Human;rat;rabbit. No cross reactivity with other proteins. |
| Reconstitution | Add 1ml of PBS buffer will yield a concentration of 100ug/ml. |
| Gene ID | 317675 |
|---|---|
| Other Names | Tryptophan 5-hydroxylase 2, 1.14.16.4, Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2, Tph2, Ntph |
| Calculated MW | 55621 MW KDa |
| Application Details | Western blot, 0.5-1 µg/ml, Human, rat, rabbit |
| Tissue Specificity | TPH1: Isoform 2 seems to be less widely expressedthan isoform 1. |
| Protein Name | Tryptophan 5-hydroxylase 1; Tryptophan 5-hydroxylase 2 |
| Contents | Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative. |
| Clone Names | WH-3 |
| Immunogen | Recombinant rabbit tryptophan hydroxylase. |
| Purification | Ascites |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. |
| Name | Tph2 |
|---|---|
| Synonyms | Ntph |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin(5-hydroxytryptamine, or 5HT). Tryptophan hydroxylase\atalyzes the biopterin-dependent monooxygenation of tryptophan to5-hydroxytryptophan(5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Human tryptophan hydroxylase(TPH) is mapped to chromosome 11p15.3-p14 by in situ hybridization.
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