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Anti-CD40/TNFRSF5 Antibody

     
  • WB - Anti-CD40/TNFRSF5 Antibody ABO10515
    Anti-CD40 antibody, ABO10515, Western blottingLane 1: Recombinant Mouse CD 40 Protein 10ngLane 2: Recombinant Mouse CD 40 Protein 5ngLane 3: Recombinant Mouse CD 40 Protein 2.5ng
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P27512
Host Rabbit
Reactivity Mouse
Clonality Polyclonal
Format lyophilized
Description Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 5(CD40) detection. Tested with WB in Mouse.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500μg/ml.
Additional Information
Gene ID 21939
Other Names Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CD40, Cd40, Tnfrsf5
Calculated MW 32093 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Mouse
Subcellular Localization Isoform I: Cell membrane; Single-pass type I membrane protein.
Protein Name Tumor necrosis factor receptor superfamily member 5
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of mouse CD40(22-36aa, QCVTCSDKQYLHDGQ).
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
Protein Information
Name Cd40
Synonyms Tnfrsf5
Function Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (PubMed:12881420).
Cellular Location [Isoform I]: Cell membrane; Single-pass type I membrane protein [Isoform IV]: Cell membrane; Single-pass type I membrane protein [Isoform II]: Secreted.
Research Areas
Citations (0)
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Background

CD40 is a cell surface receptor that is expressed on the surface of all mature B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor(TNF) receptor superfamily and is the receptor for CD40 ligand. CD40 ligand(CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.

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$ 240.00
Cat# ABO10515
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