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Anti-SDHA Antibody

     
  • WB - Anti-SDHA Antibody ABO10632
    Anti-SDHA antibody, ABO10632, Western blottingLane 1: MCF-7 Cell LysateLane 2: HELA Cell LysateLane 3: JURKAT Cell LysateLane 4: HT1080 Cell LysateLane 5: COLO320 Cell Lysate
    detail
  • IHC - Anti-SDHA Antibody ABO10632
    Anti-SDHA antibody, ABO10632, IHC(P)IHC(P): Rat Liver Tissue
    detail
  • IHC - Anti-SDHA Antibody ABO10632
    Anti-SDHA antibody, ABO10632, IHC(P)IHC(P): Human Mammary Cancer Tissue
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P31040
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Liquid
Description Rabbit IgG polyclonal antibody for Succinate dehydrogenase[ubiquinone] flavoprotein subunit, mitochondrial(SDHA) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Additional Information
Gene ID 6389
Other Names Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, 1.3.5.1, Flavoprotein subunit of complex II, Fp, SDHA, SDH2, SDHF
Calculated MW 72692 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Rat, Mouse, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse
Subcellular Localization Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Protein Name Succinate dehydrogenase[ubiquinone] flavoprotein subunit, mitochondrial
Contents Each vial contains 50% glycerol, 0.9mg NaCl, 0.2mg Na2HPO4. Carrier free (No BSA) form available in stock. If you want this antibody carrier free please specify Carrier Free" or "No BSA" in your order note. "
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human SDHA(641-656aa YRPVIDKTLNEADCAT), identical to the related rat and mouse sequences.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year, at 4˚C for one month. Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
Protein Information
Name SDHA
Synonyms SDH2, SDHF
Function Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225).
Cellular Location Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q0QF01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q0QF01}; Matrix side {ECO:0000250|UniProtKB:Q0QF01}
Research Areas
Citations (0)
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Background

Complex II of the mitochondrial respiratory chain, also known as succinate dehydrogenase or succinate:ubiquinone oxidoreductase, consists of 4 nuclear-encoded polypeptides, these are the flavoprotein subunit(SDHA), the iron sulfur protein subunit(SDHB), and the integral membrane protein subunits SDHC and SDHD. SDHA is an acronym for succinate dehydrogenase complex subunit A. The succinate dehydrogenase(SDH) protein complex catalyzes the oxidation of succinate(succinate + ubiquinone => fumarate + ubiquinol). The SDHA subunit is connected to the SDHB subunit on the hydrophilic, catalytic end of the complex, and weighs 72.7 kDA. Mutations in the SDHA subunit have a distinct pathology from mutations in the SDHB/SDHC/SDHD subunits; it is the only subunit to never have shown tumor suppressor behaviour. Heterozygous carriers of an SDHA mutation do not develop paragangliomas as has been seen for mutations in the other subunits. This appears to be due to the expression of two similar SDHA genes(Types I and II) in the paraganglia system.

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$ 280.00
Cat# ABO10632
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