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Anti-Decorin Antibody

     
  • WB - Anti-Decorin Antibody ABO10639
    Anti-Decorin antibody, ABO10639, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Kidney Tissue LysateLane 3: SMMC Cell Lysate
  • WB - Anti-Decorin Antibody ABO10639
    Anti-Decorin antibody, ABO10639, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Lung Tissue LysateLane 3: Rat Spleen Tissue LysateLane 4: SMMC Cell LysateLane 5: SMMC Cell Lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P07585
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Decorin(DCN) detection. Tested with WB in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 1634
Other Names Decorin, Bone proteoglycan II, PG-S2, PG40, DCN, SLRR1B
Calculated MW 39747 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Protein Name Decorin
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human Decorin(343-359aa TFRCVYVRSAIQLGNYK), identical to the related mouse sequence, and different from the related rat sequence by three amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Protein Information
Name DCN
Synonyms SLRR1B
Function May affect the rate of fibrils formation.
Cellular Location Secreted, extracellular space, extracellular matrix
Research Areas
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Background

Decorin is a proteoglycan on average 90-140 kilodaltons(kD) in size. The human decorin gene spans more than 38 kb and contains 8 exons and very large introns, 2 of which are 5.4 and more than 13.2 kb. And the human decorin gene is mapped to 12q21.3. It belongs to the small leucine-rich proteoglycan(SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan(GAG) chain consisting of either chondroitin sulfate(CS) or dermatan sulfate(DS). Decorin is a small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. Decorin and biglycan are though to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. And it also may play a role in epithelial/mesenchymal interactions during organ development and shaping. Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for the decorin gene. Mutations in the decorin gene are associated with congenital stromal corneal dystrophy.

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$ 240.00
Cat# ABO10639
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