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Anti-SOCS2 Antibody

     
  • WB - Anti-SOCS2 Antibody ABO10709
    Anti-SOCS2 antibody, ABO10709, Western blottingAll lanes: Anti SOCS2 (ABO10709) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Spleen Tissue Lysate at 50ugLane 3: MCF-7 Whole Cell Lysate at 40ugLane 4: HELA Whole Cell Lysate at 40ugLane 5: SMMC Whole Cell Lysate at 40ugLane 6: HT1080 Tissue Lysate at 50ugLane 7: Mouse Cardiac Muscle Tissue Lysate at 50ugLane 8: Mouse Liver Tissue Lysate at 50ugLane 9: Mouse Spleen Tissue Lysate at 50ugPredicted bind size: 22KDObserved bind size: 22KD
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O14508
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 2(SOCS2) detection. Tested with WB in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 8835
Other Names Suppressor of cytokine signaling 2, SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2, SOCS2, CIS2, SSI2, STATI2
Calculated MW 22172 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Tissue Specificity High expression in heart, placenta, lung, kidney and prostate.
Protein Name Suppressor of cytokine signaling 2(SOCS-2)
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human SOCS2(181-198aa LPLPTRLKDYLEEYKFQV), identical to the related mouse and rat sequences.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Contains 1 SH2 domain.
Protein Information
Name SOCS2
Synonyms CIS2, SSI2, STATI2
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Tissue Location High expression in heart, placenta, lung, kidney and prostate
Research Areas
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Background

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor(SSI), also known as suppressor of cytokine signalling(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma(IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor(IGF1R), and thus is though to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al.(1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.

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$ 240.00
Cat# ABO10709
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