Anti-TRAIL Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | P50592 |
Host | Rabbit |
Reactivity | Mouse, Rat |
Clonality | Polyclonal |
Format | Lyophilized |
Description | Rabbit IgG polyclonal antibody for Tumor necrosis factor ligand superfamily member 10(TNFSF10) detection. Tested with WB, IHC-P in Mouse;Rat. |
Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene ID | 22035 |
---|---|
Other Names | Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253, Tnfsf10, Trail |
Calculated MW | 33477 MW KDa |
Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Mouse, Rat, By Heat Western blot, 0.1-0.5 µg/ml, Mouse, Rat |
Subcellular Localization | Membrane ; Single-pass type II membrane protein . |
Tissue Specificity | Widespread. |
Protein Name | Tumor necrosis factor ligand superfamily member 10 |
Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of mouse TRAIL(272-291aa NEHLMDLDQEASFFGAFLIN), different from the related rat sequence by one amino acid. |
Purification | Immunogen affinity purified. |
Cross Reactivity | No cross reactivity with other proteins |
Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
Name | Tnfsf10 |
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Synonyms | Trail |
Function | Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P50591}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P50591} Secreted {ECO:0000250|UniProtKB:P50591}. Note=Exists both as membrane- bound and soluble form. {ECO:0000250|UniProtKB:P50591} |
Tissue Location | Widespread. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Tumor necrosis factor receptor superfamily member 1A(TNFRSF1A) is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. The TNFR1 gene is mapped to 12pter-cen. it encodes a protein of 455 amino acids. This receptor can activate the transcription factor NF-KB, mediate apoptosis, and function as a regulator of inflammation.
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