Anti-ADAMTS2 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F |
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Primary Accession | O95450 |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Clonality | Polyclonal |
Format | Lyophilized |
Description | Rabbit IgG polyclonal antibody for A disintegrin and metalloproteinase with thrombospondin motifs 2(ADAMTS2) detection. Tested with WB, IHC-P, IHC-F in Human;Mouse;Rat. |
Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene ID | 9509 |
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Other Names | A disintegrin and metalloproteinase with thrombospondin motifs 2, ADAM-TS 2, ADAM-TS2, ADAMTS-2, 3.4.24.14, Procollagen I N-proteinase, PC I-NP, Procollagen I/II amino propeptide-processing enzyme, Procollagen N-endopeptidase, pNPI, ADAMTS2, PCINP, PCPNI |
Calculated MW | 134755 MW KDa |
Application Details | Immunohistochemistry(Frozen Section), 0.5-1 µg/ml, Rat, Human, Mouse Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse |
Subcellular Localization | Secreted, extracellular space, extracellular matrix . |
Tissue Specificity | Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain. |
Protein Name | A disintegrin and metalloproteinase with thrombospondin motifs 2(ADAM-TS 2/ADAM-TS2/ADAMTS-2) |
Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human ADAMTS2(1189-1204aa KTRNQRIQELIDEMRK), different from the related rat and mouse sequences by three amino acids. |
Purification | Immunogen affinity purified. |
Cross Reactivity | No cross reactivity with other proteins |
Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
Sequence Similarities | Contains 1 disintegrin domain. |
Name | ADAMTS2 |
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Synonyms | PCINP, PCPNI |
Function | Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (PubMed:31152061). |
Cellular Location | Secreted, extracellular space, extracellular matrix |
Tissue Location | Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
ADAMTS2, A disintegrin and metalloproteinase with thrombospondin motifs 2, also known as procollagen I N-proteinase(PC I-NP), is an enzyme that in humans is encoded by the ADAMTS2 gene. The ADAMTS2 gene contains 22 exons. The human ADAMTS2 gene is mapped to chromosome 5q23-q24 by analysis of somatic cell hybrids. ADAMTS2 is responsible for processing several types of procollagen proteins. Procollagens are the precursors of collagens, the proteins that add strength and support to many body tissues. Specifically, this enzyme clips a short chain of amino acids off one end of the procollagen. This clipping step is necessary for collagen molecules to function normally and assemble into fibrils outside cells.
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