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Anti-AIMP2/p38 Antibody

     
  • WB - Anti-AIMP2/p38 Antibody ABO10800
    Anti-AIMP2/p38 antibody, ABO10800, Western blottingLane 1: Rat Liver Tissue LysateLane 2: Rat Lung Tissue LysateLane 3: Rat Kidney Tissue LysateLane 4: Rat Brain Tissue LysateLane 5: MarkerLane 6: JURKAT Cell LysateLane 7: CEM Cell Lysate Lane 8: HUT Cell Lysate Lane 9: U93T Cell Lysate Lane 10: U93T Cell Lysate
  • IHC - Anti-AIMP2/p38 Antibody ABO10800
    Anti-AIMP2/p38 antibody, ABO10800, IHC(P)IHC(P): Human Rectal Cancer Tissue
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q13155
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Aminoacyl tRNA synthase complex-interacting multifunctional protein 2(AIMP2) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 7965
Other Names Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38, Protein JTV-1, AIMP2, JTV1
Calculated MW 35349 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse
Subcellular Localization Cytoplasm, cytosol . Nucleus . Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. .
Protein Name Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human AIMP2/p38(298-320aa NVQRWMRSCENLAPFNTALKLLK), different from the related rat and mouse sequences by three amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Contains 1 GST C-terminal domain.
Protein Information
Name AIMP2
Synonyms JTV1
Function Required for assembly and stability of the aminoacyl- tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
Cellular Location Cytoplasm, cytosol. Nucleus {ECO:0000250|UniProtKB:Q8R010}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus {ECO:0000250|UniProtKB:Q8R010}
Research Areas
Citations (0)

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Background

AIMP2, Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2, also known as AIMP2, is an enzyme that in humans is encoded by the AIMP2 gene. AIMP2 encodes a predicted 312-amino acid protein. The AIMP2 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. AIMP2 and HRI overlap slightly and are arranged in a tail-to-tail fashion. AIMP2 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. AIMP2 is transcribed in the opposite direction compared to HRI and PMS2. AIMP2 is a scaffold required for the assembly and stability of the multi-tRNA synthetase complex. AIMP2 can work as a mediator of TGF-beta signaling and its functional importance in the control of MYC during lung differentiation.

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$ 280.00
Cat# ABO10800
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