|Application ||WB, IHC-P|
|Description||Rabbit IgG polyclonal antibody for Amine oxidase[flavin-containing] B(MAOB) detection. Tested with WB, IHC-P in Mouse;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Amine oxidase [flavin-containing] B, 220.127.116.11, Monoamine oxidase type B, MAO-B, Maob|
|Calculated MW||58558 MW KDa|
|Application Details||Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Mouse, Rat, By Heat|
Western blot, 0.1-0.5 µg/ml, Mouse, Rat
|Subcellular Localization||Mitochondrion outer membrane ; Single-pass type IV membrane protein ; Cytoplasmic side .|
|Protein Name||Amine oxidase[flavin-containing] B|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of mouse MAOB (42-56aa RTYTIRNKNVKYVDL), identical to the related rat sequence.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity).|
|Cellular Location||Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
MAOB(MONOAMINE OXIDASE B), also called MAO, BRAIN, AMINE OXIDASE(FLAVIN-CONTAINING) B, is a protein that in humans is encoded by the MAOB gene. MAOB is a member of the flavin monoamine oxidase family. And it is mapped on Xp11.3. MAOB catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. Like MAOA, it also degrades dopamine. MAO-B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviors as well as movement. MAO-B inhibition is, therefore, associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species.
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