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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-SLC2A5 Antibody   

Anti-SLC2A5 Antibody

     
  • WB - Anti-SLC2A5 Antibody ABO11045
    Anti-SLC2A5 antibody, ABO11045, Western blottingAll lanes: Anti SLC2A5 (ABO11045) at 0.5ug/mlLane 1: Rat Kidney Tissue Lysate at 50ugLane 2: Rat Liver Tissue Lysate at 50ugLane 3: Mouse Kidney Tissue Lysate at 50ugPredicted bind size: 55KDObserved bind size: 55KD
  • IHC - Anti-SLC2A5 Antibody ABO11045
    Anti-SLC2A5 antibody, ABO11045, IHC(P)IHC(P): Rat Kidney Tissue
  • IHC - Anti-SLC2A5 Antibody ABO11045
    Anti-SLC2A5 antibody, ABO11045, IHC(F)IHC(F): Rat Intestine Tissue
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-F
Primary Accession Q9WV38
Host Rabbit
Reactivity Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Solute carrier family 2, facilitated glucose transporter member 5(SLC2A5) detection. Tested with WB, IHC-P, IHC-F in Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 56485
Other Names Solute carrier family 2, facilitated glucose transporter member 5, Fructose transporter, Glucose transporter type 5, small intestine, GLUT-5, Slc2a5, Glut5
Calculated MW 55409 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Mouse, Rat, By Heat

Immunohistochemistry(Frozen Section), 0.5-1 µg/ml, Rat, Mouse
Western blot, 0.1-0.5 µg/ml, Mouse, Rat
Subcellular Localization Apical cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Localized on the apical membrane of the small intestine and the proximal tubule of the kidney.
Protein Name Solute carrier family 2, facilitated glucose transporter member 5
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of mouse SLC2A5 (232-251aa ALQTLRGWKDVHLEMEEIRK), different from the related rat sequence by two amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name Slc2a5
Synonyms Glut5
Function Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:12031501, PubMed:19091748). Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine (PubMed:19091748, PubMed:26071406). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (PubMed:19091748).
Cellular Location Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P43427}. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi (PubMed:18496516, PubMed:26071406). Transport to the cell membrane is dependent on RAB11A (PubMed:26071406)
Tissue Location Detected at the apical membrane of villi in the jejunum (PubMed:18496516, PubMed:19091748, PubMed:26071406) Detected in jejunum mucosa (PubMed:26071406). Detected in epididymis and whole testis (at protein level) (PubMed:18417103) Detected in small intestine, kidney and testis (PubMed:12031501, PubMed:18417103, PubMed:19091748). Detected in cochlea, but not in inner or outer cochlear hair cells (PubMed:18417103)
Research Areas
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Background

GLUT5(Glucose transporter 5), also known as SLC2A5, is a fructose transporter expressed on the apical border of enterocytes in the small intestine. The GLUT5 gene is located on chromosome 1. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle, testis, kidney, fat tissue, and brain. Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient. In humans the GLUT5 protein is encoded by the SLC2A5 gene.

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$ 280.00
Cat# ABO11045
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