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Anti-Dysadherin Antibody
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q96DB9 |
| Host | Rabbit |
| Reactivity | Human |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for FXYD domain-containing ion transport regulator 5(FXYD5) detection. Tested with WB, IHC-P in Human. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 53827 |
|---|---|
| Other Names | FXYD domain-containing ion transport regulator 5, Dysadherin, FXYD5, DYSAD, IWU1 |
| Calculated MW | 19472 MW KDa |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, By Heat Western blot, 0.1-0.5 µg/ml, Human |
| Subcellular Localization | Membrane ; Single-pass type I membrane protein . |
| Protein Name | FXYD domain-containing ion transport regulator 5 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human Dysadherin(165-188aa KCRQLSRLCRNRCR). |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the FXYD family. |
| Name | FXYD5 |
|---|---|
| Synonyms | DYSAD, IWU1 |
| Function | Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
FXYD5(FXYD domain-containing ion transport regulator 5), also known as Dysadherin, is a protein that in humans is encoded by the FXYD5 gene. The gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The FXYD5 gene is mapped on 19q13.12. The deduced FXYD5 protein, the largest of the 7, contains 178 amino acids and has a signal peptide. Immunoreactivity for dysadherin, localized at cell-cell boundaries, was detected in 39 of 51 papillary carcinomas and in all 31 undifferentiated carcinomas but not in the follicular carcinomas or normal thyroid tissue controls. Dysadherin expression was significantly higher in undifferentiated carcinoma than in papillary carcinoma or follicular carcinoma and showed significant negative correlation with E-cadherin expression.
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