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Anti-Peroxiredoxin 5 Antibody

     
  • WB - Anti-Peroxiredoxin 5 Antibody ABO11146
    Anti-Peroxiredoxin 5 antibody, ABO11146, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Lung Tissue LysateLane 3: Rat Liver Tissue LysateLane 4: Rat Kidney Tissue LysateLane 5: HELA Cell Lysate Lane 6: 293T Cell LysateLane 7: MCF-7 Cell LysateLane 8: A549 Cell Lysate
    detail
  • IHC - Anti-Peroxiredoxin 5 Antibody ABO11146
    Anti-Peroxiredoxin 5 antibody, ABO11146, IHC(P)IHC(P): Human Prostatic Cancer Tissue
    detail
  • IHC - Anti-Peroxiredoxin 5 Antibody ABO11146
    Anti-Peroxiredoxin 5 antibody, ABO11146, IHC(P)IHC(P): Rat Liver Tissue
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P30044
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Peroxiredoxin-5, mitochondrial(PRDX5) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 25824
Other Names Peroxiredoxin-5, mitochondrial, 1.11.1.15, Alu corepressor 1, Antioxidant enzyme B166, AOEB166, Liver tissue 2D-page spot 71B, PLP, Peroxiredoxin V, Prx-V, Peroxisomal antioxidant enzyme, TPx type VI, Thioredoxin peroxidase PMP20, Thioredoxin reductase, PRDX5, ACR1
Calculated MW 22086 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse
Subcellular Localization Isoform Mitochondrial: Mitochondrion.
Tissue Specificity Widely expressed. .
Protein Name Peroxiredoxin-5, mitochondrial
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 5(166-181aa DDSLVSIFGNRRLKRF), identical to the related mouse and rat sequences.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the peroxiredoxin 2 family.
Protein Information
Name PRDX5 (HGNC:9355)
Synonyms ACR1
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Cellular Location [Isoform Mitochondrial]: Mitochondrion
Tissue Location Widely expressed..
Research Areas
Citations (0)
citation

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Background

PRDX5(peroxiredoxin 5) also known as AOEB166, ACR1,B166, MGC117264, MGC142283, MGC142285, PLP, PMP20, PRDX6, PRXV, SBBI10, is a member of the peroxiredoxin family and may play an antioxidant protective role in various tissues under nonpathologic conditions and during inflammatory processes. The PRDX5 gene is mapped on 11q13.1. PRDX5 displays mitochondrial presequence features and has 3 cysteines implicated in antioxidant activity and a C-terminal SQL peroxisomal targeting sequence. Northern blot analysis revealed ubiquitous expression of a 1.0-kb PRDX5 transcript in tissues and cell lines. Functional analysis showed that PRDX5 has antioxidant activity equivalent to that of CAT. While PRDX5 was localized to fibroblasts in normal tendon, it was localized to fibroblasts and endothelial cells in degenerative tendon. PRDX5 mRNA and protein levels increased at 12 hours, and the increase in PRDX5 expression correlated with reduced peroxide levels. PRDX5 plays a protective role against oxidative stress in human cartilage.

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$ 280.00
Cat# ABO11146
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