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Anti-Flavin Containing Monooxygenase 4 Antibody
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P31512 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Dimethylaniline monooxygenase[N-oxide-forming] 4(FMO4) detection. Tested with WB, IHC-P in Human;Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 2329 |
|---|---|
| Other Names | Dimethylaniline monooxygenase [N-oxide-forming] 4, 1.14.13.8, Dimethylaniline oxidase 4, Hepatic flavin-containing monooxygenase 4, FMO 4, FMO4, FMO2 |
| Calculated MW | 63343 MW KDa |
| Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Rat, Human, By Heat Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat |
| Subcellular Localization | Microsome membrane. Endoplasmic reticulum membrane. |
| Tissue Specificity | Liver. |
| Protein Name | Dimethylaniline monooxygenase [N-oxide-forming] 4 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human Flavin containing monooxygenase 4(75-92aa HEDYPNFMNHEKFWDYLQ), different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Sequence Similarities | Belongs to the FMO family. |
| Name | FMO4 |
|---|---|
| Synonyms | FMO2 |
| Function | This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. |
| Cellular Location | Microsome membrane {ECO:0000250|UniProtKB:Q8K4B7}; Single-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8K4B7}; Single-pass membrane protein |
| Tissue Location | Liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
FMO4(Flavin-containing monooxygenase 4) also known as FMO2, FORMERLY or FMO, ADULT LIVER FORM, is an enzyme that in humans is encoded by the FMO4 gene. By PCR analysis, Dolphin et al.(1992) mapped the FMO4 gene to chromosome 1. Southern blot hybridization with single exon probes demonstrated that human FMO4 and FMO1 are, in each case, the product of a single gene. Lawton et al.(1994) proposed a reclassification of mammalian FMOs. Under this system, FMO2 described by Dolphin et al.(1992) is now designated FMO4.
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