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Anti-TNFRSF4/OX40 Antibody

     
  • WB - Anti-TNFRSF4/OX40 Antibody ABO11445
    Anti-CD134/OX40 antibody, ABO11445, Western blottingLane 1: Mouse Brain Tissue LysateLane 2: Mouse Spleen Tissue LysateLane 3: Mouse Liver Tissue Lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P47741
Host Rabbit
Reactivity Mouse
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 4(TNFRSF4) detection. Tested with WB in Mouse.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Other Names Tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor, CD134, Tnfrsf4, Ox40, Txgp1
Calculated MW 30154 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Mouse
Subcellular Localization Membrane; Single-pass type I membrane protein.
Protein Name Tumor necrosis factor receptor superfamily member 4
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of mouse CD134(22-43aa ARRLNCVKHTYPSGHKCCRECQ).
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name Tnfrsf4
Synonyms Ox40, Txgp1
Function Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein EMBL; Z21674; CAA79772.1; -; mRNA EMBL; X85214; CAA59476.1; -; Genomic_DNA CCDS; CCDS19055.1; - PIR; I48700; I48700 RefSeq; NP_035789.1; NM_011659.2 UniGene; Mm.13885; - ProteinModelPortal; P47741; - SMR; P47741; - DIP; DIP-6239N; - IntAct; P47741; 13 STRING; 10090.ENSMUSP00000030952; - EPD; P47741; - PaxDb; P47741; - PRIDE; P47741; - GeneID; 22163; - KEGG; mmu:22163; - CTD; 7293; - MGI; MGI:104512; Tnfrsf4 eggNOG; ENOG410J0US; Eukaryota eggNOG; ENOG4111DUJ; LUCA HOGENOM; HOG000049154; - HOVERGEN; HBG005031; - InParanoid; P47741; - KO; K05142; - PhylomeDB; P47741; - PRO; PR:P47741; - Proteomes; UP000000589; Unplaced GO; GO:0009986; C:cell surface; ISO:MGI GO; GO:0009897; C:external side of plasma membrane; IDA:MGI GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central GO; GO:0005886; C:plasma membrane; IDA:MGI GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IPI:MGI GO; GO:0006968; P:cellular defense response; IMP:MGI GO; GO:0006955; P:immune response; IBA:GO_Central GO; GO:0006954; P:inflammatory response; IMP:MGI GO; GO:0007275; P:multicellular organism development; IBA:GO_Central GO; GO:0070236; P:negative regulation of activation-induced cell death of T cells; IMP:BHF-UCL GO; GO:0050710; P:negative regulation of cytokine secretion; IPI:MGI GO; GO:0043433; P:negative regulation of DNA binding transcription factor activity; IDA:BHF-UCL GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:BHF-UCL GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:BHF-UCL GO; GO:0030890; P:positive regulation of B cell proliferation; IMP:BHF-UCL GO; GO:0051024; P:positive regulation of immunoglobulin secretion; IDA:BHF-UCL GO; GO:0042981; P:regulation of apoptotic process; IMP:MGI GO; GO:0045859; P:regulation of protein kinase activity; IMP:MGI GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central GO; GO:0042098; P:T cell proliferation; ISO:MGI CDD; cd13406; TNFRSF4; 1 InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg InterPro; IPR020445; TNFR_4 InterPro; IPR034022; TNFRSF4_N InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like Pfam; PF00020; TNFR_c6; 2 PRINTS; PR01921; TNFACTORR4 SMART; SM01411; Ephrin_rec_like; 2 SMART; SM00208; TNFR; 3 PROSITE; PS00652; TNFR_NGFR_1; 2 PROSITE; PS50050; TNFR_NGFR_2; 2 1: Evidence at protein level; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 19 CHAIN 20 272 Tumor necrosis factor receptor superfamily member 4 /FTId=PRO_0000034555 TOPO_DOM 20 211 Extracellular. TRANSMEM 212 236 Helical. TOPO_DOM 237 272 Cytoplasmic. REPEAT 26 61 TNFR-Cys 1 REPEAT 62 103 TNFR-Cys 2 REPEAT 104 124 TNFR-Cys 3; truncated REPEAT 125 165 TNFR-Cys 4 CARBOHYD 144 144 N-linked (GlcNAc...) asparagine DISULFID 27 38 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 39 52 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 42 60 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 63 77 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 80 95 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 83 103 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 105 123 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 126 139 {ECO:0000255|PROSITE-ProRule:PRU00206} DISULFID 145 164 {ECO:0000255|PROSITE-ProRule:PRU00206} CONFLICT 15 15 A -> G (in Ref. 2; CAA59476) SEQUENCE 272 AA; 30154 MW; 06E7BB4156F0D08E CRC64; MYVWVQQPTA LLLLALTLGV TARRLNCVKH TYPSGHKCCR ECQPGHGMVS RCDHTRDTLC HPCETGFYNE AVNYDTCKQC TQCNHRSGSE LKQNCTPTQD TVCRCRPGTQ PRQDSGYKLG VDCVPCPPGH FSPGNNQACK PWTNCTLSGK QTRHPASDSL DAVCEDRSLL ATLLWETQRP TFRPTTVQST TVWPRTSELP SPPTLVTPEG PAFAVLLGLG LGLLAPLTVL LALYLLRKAW RLPNTPKPCW GNSFRTPIQE EHTDAHFTLA KI
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Background

Tumor necrosis factor receptor superfamily, member4, also known as ACT35 or CD134 is a cell surface glycoprotein that was discovered through the production of a monoclonal antibody raised against the HUT-102 cell line. It belongs to the tumor necrosis factor receptor superfamily. CD134 was mapped to 1p36 by fluorescence in situ hybridization. CD134 is the primary receptor for feline immunodeficiency virus. CD134 expression can promote viral binding and renders cells permissive for viral entry, productive infection, and syncytium formation. Stimulating the receptor can improve the response to a powerful virus vector and may be useful in vaccine development.

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$ 240.00
Cat# ABO11445
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