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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Solute Carrier Family 22 Member 5 Antibody   

Anti-Solute Carrier Family 22 Member 5 Antibody

     
  • WB - Anti-Solute Carrier Family 22 Member 5 Antibody ABO11484
    Anti-Solute carrier family 22 member 5 antibody, ABO11484, Western blottingLane 1: Rat Kidney Tissue LysateLane 2: Rat Skeletal Muscles Tissue LysateLane 3: Mouse Liver Tissue LysateLane 4: HEPA Cell LysateLane 5: NIH3T3 Cell Lysate
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9Z0E8
Host Rabbit
Reactivity Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Solute carrier family 22 member 5(SLC22A5) detection. Tested with WB in Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 20520
Other Names Solute carrier family 22 member 5, High-affinity sodium-dependent carnitine cotransporter, Organic cation/carnitine transporter 2, Slc22a5, Octn2
Calculated MW 62780 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Mouse, Rat
Subcellular Localization Apical cell membrane ; Multi-pass membrane protein . Colocalizes with PDZK1 on apical membranes of kidney proximal tubules.
Tissue Specificity Widely expressed. Expressed in kidney, liver and testis. .
Protein Name Solute carrier family 22 member 5
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of mouse Solute carrier family 22 member 5(531-547aa KQWQIQSQTRMQKDGEE), different from the related rat sequence by two amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name Slc22a5
Synonyms Octn2
Function Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Cellular Location Apical cell membrane; Multi-pass membrane protein. Note=Colocalizes with PDZK1 on apical membranes of kidney proximal tubules
Tissue Location Widely expressed. Expressed in kidney, liver and testis.
Research Areas
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Background

Solute carrier family 22(organic cation/carnitine transporter), member 5, also called SLC22A5 or OCTN2 is a membrane transport protein associated with primary carnitine deficiency. This gene is mapped to 5q31.1. Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency(CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.

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$ 240.00
Cat# ABO11484
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