Anti-FbxL4 Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | Q9UKA2 |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Clonality | Polyclonal |
Format | Lyophilized |
Description | Rabbit IgG polyclonal antibody for F-box/LRR-repeat protein 4(FBXL4) detection. Tested with WB, IHC-P in Human;Mouse;Rat. |
Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Gene ID | 26235 |
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Other Names | F-box/LRR-repeat protein 4, F-box and leucine-rich repeat protein 4, F-box protein FBL4/FBL5, FBXL4, FBL4, FBL5 |
Calculated MW | 70097 MW KDa |
Application Details | Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat, By Heat Western blot, 0.1-0.5 µg/ml, Human, Rat, Mouse |
Subcellular Localization | Cytoplasm. Nucleus. Mitochondrion. |
Tissue Specificity | Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle. . |
Protein Name | F-box/LRR-repeat protein 4 |
Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human FbxL4(552-565aa DELASNCTRLQQLD), different from the related mouse and rat sequences by one amino acid. |
Purification | Immunogen affinity purified. |
Cross Reactivity | No cross reactivity with other proteins |
Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
Sequence Similarities | Contains 1 F-box domain. |
Name | FBXL4 |
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Synonyms | FBL4, FBL5 |
Cellular Location | Cytoplasm. Nucleus. Mitochondrion. |
Tissue Location | Expressed in heart, kidney, liver, lung, pancreas, and placenta, but not in skeletal muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
FBXL4, also known as FBL4 or FBL5 encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. This gene is mapped to 6q16.1. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A.
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