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Anti-muscarinic Acetylcholine Receptor 1 Antibody

     
  • WB - Anti-muscarinic Acetylcholine Receptor 1 Antibody ABO11512
    Anti-muscarinic Acetylcholine Receptor 1 antibody, ABO11512, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue LysateLane 3: U87 Cell LysateLane 4: SHG Cell LysateLane 5: NEURO Cell LysateLane 6: HELA Cell Lys
    detail
  • IHC - Anti-muscarinic Acetylcholine Receptor 1 Antibody ABO11512
    Anti-muscarinic Acetylcholine Receptor 1 antibody, ABO11512, IHC(P)IHC(P): Rat Brain Tissue
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P11229
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Muscarinic acetylcholine receptor M1(CHRM1) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 1128
Other Names Muscarinic acetylcholine receptor M1, CHRM1
Calculated MW 51421 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Rat, Human, Mouse, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Protein Name Muscarinic acetylcholine receptor M1
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human muscarinic Acetylcholine Receptor 1(303-317aa KMPMVDPEAQAPTKQ), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name CHRM1
Function The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Cellular Location Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)
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Background

Muscarinic acetylcholine receptor M1, also known as cholinergic receptor, muscarinic 1, is a muscarinic receptor. This gene is mapped to 11q12.3. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract.

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$ 280.00
Cat# ABO11512
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