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Anti-Reticulon 1 Antibody

     
  • WB - Anti-Reticulon 1 Antibody ABO11565
    Anti-Reticulon 1 antibody, ABO11565, All Western blottingAll lanes: Anti-RTN1(ABO11565) at 0.5ug/mlLane 1: Rat Lung Tissue Lysate at 40ugPredicted bind size: 84KDObserved bind size: 84KD
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q16799
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Reticulon-1(RTN1) detection. Tested with WB in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 6252
Other Names Reticulon-1, Neuroendocrine-specific protein, RTN1, NSP
Calculated MW 83618 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Rat, Human, Mouse
Subcellular Localization Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation. .
Protein Name Reticulon-1
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human Reticulon 1(121-136aa TYFTGILQKENGHVTI), different from the related mouse and rat sequences by three amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name RTN1
Synonyms NSP
Function Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation
Research Areas
Citations (0)
citation

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Background

Reticulon-1, also called RTN1 or NSP, is a protein that in humans is encoded by the RTN1 gene. It is mapped to 14q23.1. This gene belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. RTN1 has been shown to interact with BCL2-like 1, UGCG and spastin which is mutated in hereditary spastic paraplegia-4.

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$ 240.00
Cat# ABO11565
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