|Reactivity||Human, Mouse, Rat|
|Description||Rabbit IgG polyclonal antibody for Follicle-stimulating hormone receptor(FSH-R)(FSHR) detection. Tested with WB in Human;Mouse;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Follicle-stimulating hormone receptor, FSH-R, Follitropin receptor, FSHR, LGR1|
|Calculated MW||78265 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein.|
|Tissue Specificity||Sertoli cells and ovarian granulosa cells.|
|Protein Name||Follicle-stimulating hormone receptor(FSH-R)|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||E. coli-derived human FSH Receptor recombinant protein (Position: C18-N187). Human FSH Receptor shares 91.2% and 90% amino acid (aa) sequence identity with mouse and rat FSH Receptor, respectively.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins.|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690).|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Sertoli cells and ovarian granulosa cells.|
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Provided below are standard protocols that you may find useful for product applications.
The follicle-stimulating hormone receptor or FSH receptor (FSHR) is a transmembrane receptor that interacts with the follicle-stimulating hormone (FSH) and represents a G protein-coupled receptor (GPCR). This FSHR gene is mapped to chromosome 2p21 by fluorescence in situ hybridization. The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
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