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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-ALOX15 Picoband Antibody   

Anti-ALOX15 Picoband Antibody

     
  • IHC - Anti-ALOX15 Picoband Antibody ABO11788
    Anti-ALOX15 Picoband antibody, ABO11788-1.JPGIHC(P): Mouse Lung Tissue
  • IHC - Anti-ALOX15 Picoband Antibody ABO11788
    Anti-ALOX15 Picoband antibody, ABO11788-2.JPGIHC(P): Rat Lung Tissue
  • IHC - Anti-ALOX15 Picoband Antibody ABO11788
    Anti-ALOX15 Picoband antibody, ABO11788-3.JPGIHC(P): Human Intestine Cancer Tissue
  • IHC - Anti-ALOX15 Picoband Antibody ABO11788
    Anti-ALOX15 Picoband antibody, ABO11788-4.JPGIHC(P): Human Mammary Cancer Tissue
  • WB - Anti-ALOX15 Picoband Antibody ABO11788
    Anti-ALOX15 Picoband antibody, ABO11788-5.jpgAll lanes: Anti-ALOX15(ABO11788) at 0.5ug/mWB: Recombinant Human ALOX15 Protein 0.5ngPredicted bind size: 39KDObserved bind size: 39KD
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P16050
Host Rabbit
Reactivity Human
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Arachidonate 15-lipoxygenase(ALOX15) detection. Tested with WB, IHC-P in Human.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 246
Other Names Arachidonate 15-lipoxygenase, 15-LOX, 15-LOX-1, 1.13.11.33, 12/15-lipoxygenase, Arachidonate 12-lipoxygenase, leukocyte-type, 12-LOX, 1.13.11.31, Arachidonate omega-6 lipoxygenase, ALOX15, LOG15
Calculated MW 74804 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, By Heat
Western blot, 0.1-0.5 µg/ml, Human
Subcellular Localization Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.
Tissue Specificity Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. .
Protein Name Arachidonate 15-lipoxygenase
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen E.coli-derived human ALOX15 recombinant protein (Position: G2-P337). Human ALOX15 shares 72% and 73% amino acid (aa) sequences identity with mouse and rat ALOX15, respectively.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the lipoxygenase family.
Protein Information
Name ALOX15
Synonyms LOG15
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12- hydroperoxyeicosatetraenoic acid/12-HPETE and 15- hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.
Cellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells
Tissue Location Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells
Research Areas
Citations (0)

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Background

Arachidonate 15-lipoxygenase, also known as 15 LOX or LOG15, is an enzyme that in humans is encoded by the ALOX15 gene. This gene is mapped to 17p13.2. It is found that ALOX15 is a mutator gene. ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. Loss of the TP53 gene, or gain-of-function activities resulting from the expression of its mutant forms regulates ALOX15 promoter activity in human and in mouse, albeit in directionally opposite manners.

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$ 280.00
Cat# ABO11788
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