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Anti-GRIK1 Picoband Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P39086 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Format | Lyophilized |
| Description | Rabbit IgG polyclonal antibody for Glutamate receptor ionotropic, kainate 1(GRIK1) detection. Tested with WB in Human;Mouse;Rat. |
| Reconstitution | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
| Gene ID | 2897 |
|---|---|
| Other Names | Glutamate receptor ionotropic, kainate 1, GluK1, Excitatory amino acid receptor 3, EAA3, Glutamate receptor 5, GluR-5, GluR5, GRIK1, GLUR5 |
| Calculated MW | 103981 MW KDa |
| Application Details | Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus. |
| Protein Name | Glutamate receptor ionotropic, kainate 1 |
| Contents | Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
| Immunogen | E.coli-derived human GRIK1 recombinant protein (Position: R271-I450). Human GRIK1 shares 88% and 94% amino acid (aa) sequences identity with mouse and rat GRIK1, respectively. |
| Purification | Immunogen affinity purified. |
| Cross Reactivity | No cross reactivity with other proteins |
| Storage | At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing. |
| Name | GRIK1 |
|---|---|
| Synonyms | GLUR5 |
| Function | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein |
| Tissue Location | Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glutamate receptor, ionotropic, kainate 1, also known as GLUR5, is a protein that in humans is encoded by the GRIK1 gene. It is mapped to 21q21.3. This gene encodes one of the many ionotropic glutamate receptor (GluR) subunits that function as a ligand-gated ion channel. The specific GluR subunit encoded by this gene is of the kainate receptor subtype. Receptor assembly and intracellular trafficking of ionotropic glutamate receptors are regulated by RNA editing and alternative splicing. These receptors mediate excitatory neurotransmission and are critical for normal synaptic function. Exons of this gene are interspersed with exons from the C21or f41 gene, which is transcribed in the same orientation as this gene but does not seem to encode a protein.
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