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Anti-p73 Picoband Antibody

     
  • WB - Anti-p73 Picoband Antibody ABO11926
    Anti- p73 antibody, ABO11926, Western blottingAll lanes: Anti p73 (ABO11926) at 0.5ug/mlWB: Recombinant Human p73 Protein 0.5ngPredicted bind size: 45KDObserved bind size: 45KD
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  • WB - Anti-p73 Picoband Antibody ABO11926
    Anti- p73 antibody, ABO11926, Western blottingAll lanes: Anti p73 (ABO11926) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: COLO320 Whole Cell Lysate at 40ugPredicted bind size: 73KDObserved bind size: 73KD
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  • IHC - Anti-p73 Picoband Antibody ABO11926
    Anti- p73 antibody, ABO11926, IHC(P)IHC(P): Human Intestinal Cancer Tissue
    detail
  • IHC - Anti-p73 Picoband Antibody ABO11926
    Anti- p73 antibody, ABO11926, IHC(P)IHC(P): Rat Brain Tissue
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  • IHC - Anti-p73 Picoband Antibody ABO11926
    Anti- p73 antibody, ABO11926, IHC(P)IHC(P): Mouse Intestine Tissue
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O15350
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Tumor protein p73(TP73) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 7161
Other Names Tumor protein p73, p53-like transcription factor, p53-related protein, TP73, P73
Calculated MW 69623 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5 µg/ml, Human
Subcellular Localization Nucleus . Cytoplasm. Accumulates in the nucleus in response to DNA damage.
Tissue Specificity Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. .
Protein Name Tumor protein p73
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen E.coli-derived human p73 recombinant protein (Position: M1-E198). Human p73 shares 96% amino acid (aa) sequence identity with mouse p73.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the p53 family.
Protein Information
Name TP73
Synonyms P73
Function Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761).
Cellular Location Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage
Tissue Location Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas Highly expressed in fetal tissue. Expressed in the respiratory epithelium (PubMed:34077761).
Research Areas
Citations (0)
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Background

p73, also known as tumor protein 73(TP73), encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It is mapped to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Furthermore, recent finding are suggesting that over-expression of transcription factors involved in cell cycle regulation and synthesis of DNA in mammalian cells (e.g.: E2F-1) induces the expression of p73. In addition, p73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate p73 is markedly increased by gamma-irradiation.

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$ 280.00
Cat# ABO11926
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