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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Peroxiredoxin 1 Picoband Antibody   

Anti-Peroxiredoxin 1 Picoband Antibody

     
  • WB - Anti-Peroxiredoxin 1 Picoband Antibody ABO12039
    Anti- Peroxiredoxin 1 Picoband antibody, ABO12039, Western blottingAll lanes: Anti Peroxiredoxin 1 (ABO12039) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: Mouse Brain Tissue Lysate at 50ugLane 3: U87 Whole Cell Lysate at 40ugLane 4: NEURO Whole Cell Lysate at 40ugLane 5: A375 Whole Cell Lysate at 40ugLane 6: 293T Whole Cell Lysate at 40ugLane 7: SMMC Whole Cell Lysate at 40ugLane 8: A549 Whole Cell Lysate at 40ugLane 9: RH35 Whole Cell Lysate at 40ugPredicted bind size: 22KDObserved bind size: 22KD
  • IHC - Anti-Peroxiredoxin 1 Picoband Antibody ABO12039
    Anti- Peroxiredoxin 1 Picoband antibody, ABO12039, IHC(P)IHC(P): Mouse Brain Tissue
  • IHC - Anti-Peroxiredoxin 1 Picoband Antibody ABO12039
    Anti- Peroxiredoxin 1 Picoband antibody, ABO12039, IHC(P)IHC(P): Rat Brain Tissue
  • IHC - Anti-Peroxiredoxin 1 Picoband Antibody ABO12039
    Anti- Peroxiredoxin 1 Picoband antibody, ABO12039, IHC(P)IHC(P): Huma Mammary Cancer Tissue
  • ICC - Anti-Peroxiredoxin 1 Picoband Antibody ABO12039
    Anti- Peroxiredoxin 1 Picoband antibody, ABO12039, ICCICC: SMMC-7721 Cell
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession Q06830
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Peroxiredoxin-1(PRDX1) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 5052
Other Names Peroxiredoxin-1, 1.11.1.15, Natural killer cell-enhancing factor A, NKEF-A, Proliferation-associated gene protein, PAG, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, PRDX1, PAGA, PAGB, TDPX2
Calculated MW 22110 MW KDa
Application Details Immunocytochemistry , 0.5-1 µg/ml, Human, -
Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Subcellular Localization Cytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Name Peroxiredoxin-1
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human Peroxiredoxin 1 (100-128aa MNIPLVSDPKRTIAQDYGVLKADEGISFR), different from the related mouse sequence by one amino acid, and identical to the related rat sequence.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins.
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the AhpC/TSA family.
Protein Information
Name PRDX1
Synonyms PAGA, PAGB, TDPX2
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
Cellular Location Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Research Areas
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Background

PRDX1(Peroxiredoxin 1), also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is mapped on 1p34.1. Prdx1 was expressed in differentiating motor neuron cells in developing embryonic chicken and mouse spinal cords. mmunoprecipitation analysis showed that GDE2 interacted directly with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein may have a proliferative effect and play a role in cancer development or progression. In differentiating spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2 for the induction of motor neuron differentiation.

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$ 280.00
Cat# ABO12039
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