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Anti-ADRB2 Picoband Antibody

     
  • WB - Anti-ADRB2 Picoband Antibody ABO12056
    Anti- ADRB2 Picoband antibody, ABO12056, Western blottingAll lanes: AntiADRB2 (ABO12056) at 0.5ug/mlWB: Rat Brain Tissue Lysate at 50ugPredicted bind size: 47KDObserved bind size: 47KD
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P07550
Host Rabbit
Reactivity Human, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Beta-2 adrenergic receptor(ADRB2) detection. Tested with WB in Human;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 154
Other Names Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor, ADRB2, ADRB2R, B2AR
Calculated MW 46459 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Rat, Human
Subcellular Localization Cell membrane ; Multi-pass membrane protein . Colocalizes with VHL at the cell membrane.
Protein Name Beta-2 adrenergic receptor
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human ADRB2(221-256aa RVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGH), different from the related mouse and rat sequences by three amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins.
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.
Protein Information
Name ADRB2
Synonyms ADRB2R, B2AR
Function Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Cellular Location Cell membrane; Multi- pass membrane protein. Early endosome. Note=Colocalizes with VHL at the cell membrane (PubMed:19584355). Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325).
Research Areas
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Background

ADRB2, also known as beta-2 adrenergic receptor, is a beta-adrenergic receptor within a cell membrane which reacts with adrenaline (epinephrine) as a hormone or neurotransmitter affecting muscles or organs. It is mapped to 5q32. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. The genetic variation in the ADRB2 gene may be of major importance for obesity, energy expenditure, and lipolytic ADRB2 function in adipose tissue, at least in women. What’s more, it has been found that activation of ADRB2 receptors can stimulate gamma-secretase activity and beta-amyloid production, and the ADRB2 receptors activator may contribute to beta-amyloid accumulation in AD.

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$ 240.00
Cat# ABO12056
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