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Anti-CACYBP Antibody

     
  • WB - Anti-CACYBP Antibody ABO12780
    Western blot analysis of CACYBP expression in rat brain extract (lane 1), mouse testis extract (lane 2) and SW620 whole cell lysates (lane 3). CACYBP at 26KD was detected using rabbit anti-CACYBP Antigen Affinity purified polyclonal antibody (Catalog # ABO12780) at 0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method .
    detail
  • IHC - Anti-CACYBP Antibody ABO12780
    CACYBP was detected in paraffin-embedded sections of mouse testis tissues using rabbit anti- CACYBP Antigen Affinity purified polyclonal antibody (Catalog # ABO12780) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-CACYBP Antibody ABO12780
    CACYBP was detected in paraffin-embedded sections of rat testis tissues using rabbit anti- CACYBP Antigen Affinity purified polyclonal antibody (Catalog # ABO12780) at 1 μg/mL. The immunohistochemical section was developed using SABC method .
    detail
  • IHC - Anti-CACYBP Antibody ABO12780
    CACYBP was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- CACYBP Antigen Affinity purified polyclonal antibody (Catalog # ABO12780) at 1 ??g/mL. The immunohistochemical section was developed using SABC method .
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9HB71
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Calcyclin-binding protein(CACYBP) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 27101
Other Names Calcyclin-binding protein, CacyBP, hCacyBP, S100A6-binding protein, Siah-interacting protein, CACYBP, S100A6BP, SIP
Calculated MW 26210 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat, By Heat

Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Subcellular Localization Nucleus . Cytoplasm . Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.
Protein Name Calcyclin-binding protein
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human CACYBP (7-47aa QKDLEEVKVLLEKATRKRVRDALTAEKSKIETEIKNKMQQK), different from the related mouse sequence by five amino acids, and from the related rat sequence by six amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name CACYBP
Synonyms S100A6BP, SIP
Function May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
Cellular Location Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated
Research Areas
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Background

Calcyclin-binding protein is a protein that in humans is encoded by the CACYBP gene. And this gene is mapped to 1q24-q25. The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. In addition, it probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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$ 280.00
Cat# ABO12780
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