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FADD Antibody (Clone T1B)

Mouse Monoclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession Q13158
Other Accession NM_003824
Reactivity Human, Mouse, Dog
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names T1B
Calculated MW 23279 Da
Additional Information
Gene ID 8772
Application & Usage Western blot analysis (1-4 µg/ml). The antibody detects 28 kDa protein, corresponding to the apparent molecular weight of FADD in SDS-PAGE However, the optimal conditions should be determined individually. HeLa cell lysate can be used as a positive control.immunoblots from samples of human and mouse origins.
Other Names FAS-associated death domain protein, GIG3, MGC8528, MORT1
Target/Specificity FADD
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (200 µg/ml) affinity purified antibody in PBS containing 30% glycerol, 0.5% BSA and 0.01% thimerosal
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsFADD Antibody (Clone T1B) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FADD {ECO:0000303|PubMed:7538907, ECO:0000312|HGNC:HGNC:3573}
Function Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors (PubMed:7538907, PubMed:23955153, PubMed:19118384, PubMed:20935634, PubMed:16762833, PubMed:24025841). The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation (PubMed:7538907, PubMed:19118384, PubMed:20935634, PubMed:16762833). Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon- mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225).
Tissue Location Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Research Areas
Citations (0)
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Background

Fas-associating death domain containing protein (FADD), also known as mediator of receptor induced toxicity (MORT1), is a 24 kDa cytosolic protein. The protein is involved in both Fas and TNF-R induced cell death pathway. FADD specifically binds to Fas, an association mediated by their homologous death domains. Overexpression of FADD induces apoptosis that can be inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death.

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Discontinued
Cat# ABV10003-100
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