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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FADD Antibody (Clone T1B)   

FADD Antibody (Clone T1B)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13158
Other Accession NM_003824
Reactivity Human, Mouse, Dog
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names T1B
Calculated MW 23279 Da
Additional Information
Gene ID 8772
Application & Usage Western blot analysis (1-4 µg/ml). The antibody detects 28 kDa protein, corresponding to the apparent molecular weight of FADD in SDS-PAGE However, the optimal conditions should be determined individually. HeLa cell lysate can be used as a positive control.immunoblots from samples of human and mouse origins.
Other Names FAS-associated death domain protein, GIG3, MGC8528, MORT1
Target/Specificity FADD
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (200 µg/ml) affinity purified antibody in PBS containing 30% glycerol, 0.5% BSA and 0.01% thimerosal
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsFADD Antibody (Clone T1B) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MORT1
Function Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Tissue Location Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes
Research Areas
Citations (0)

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Fas-associating death domain containing protein (FADD), also known as mediator of receptor induced toxicity (MORT1), is a 24 kDa cytosolic protein. The protein is involved in both Fas and TNF-R induced cell death pathway. FADD specifically binds to Fas, an association mediated by their homologous death domains. Overexpression of FADD induces apoptosis that can be inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death.

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$ 295.00
Cat# ABV10003
(40 western blots)
Availability: 5-7days
Bulk Size
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