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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Caspase-7 Antibody (Clone B4-G2)   

Caspase-7 Antibody (Clone B4-G2)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P55210
Other Accession BAG61059
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names B4-G2
Calculated MW 34277 Da
Additional Information
Gene ID 840
Application & Usage Western blot analysis (0.5-2 µg/ml) and immunoprecipitation (4-10 µg/ml). However the optimal conditions should be determined individually. Detects both pro-caspase-7 (34 kDa) and the large subunit of cleaved caspase-7 (19 kDa) in apoptosis cells on SDS-PAGE immunoblots.
Other Names CASP7, CASP-7, ICE-LAP3, CMH-1, MCH3, EC
Target/Specificity Caspase-7
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 µg/ml) in PBS containing 1 mg/ml BSA and 1.5 mM thimerosal and 50% glycerol
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCaspase-7 Antibody (Clone B4-G2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASP7
Synonyms MCH3
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain
Research Areas
Citations (0)

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The caspase family of cysteine proteases plays a key role in apoptosis. Caspase-7, also known as Mch3α, ICE/LAP3 and CMH1, is a 34 kDa protein that is activated during Fas- and TNF-induced apoptosis. Caspase-7 has been identified as a major contributor to the execution phase of cellular apoptosis. It cleaves essential cellular machinery following its own cleavage from an inactive proenzyme to an active heterodimeric form. Caspase-7 is processed by caspase-3, -6, -8, -9, and –10 as well as by Granzyme B.

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$ 295.00
Cat# ABV10005
(40 western blots)
Availability: 5-7days
Bulk Size
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