|Calculated MW||42742 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). The antibody detects procaspase-11 (45 kDa), a partially cleaved fragment (30 kDa) and fully cleaved fragment (20 kDa). A 58 kDa unknown identity band was also detected in 3T3 cells.|
|Other Names||CASP-11, ICEB, ICH-3|
|Formulation||100 µg (0.2 mg/ml) protein A purified rabbit anti-caspase-11 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Caspase-11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Casp11, Caspl, Ich3|
|Function||Involved in ER-stress induced apoptosis. Cleaves caspase-1 (By similarity). Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses.|
|Cellular Location||Endoplasmic reticulum membrane. Mitochondrion|
|Tissue Location||Mostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain|
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Provided below are standard protocols that you may find useful for product applications.
Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-11 is also synthesized as inactive pro-enzyme that are processed in cells undergoing apoptosis or inflammation. The processed form of caspase-11 consists of large and small subunits which associate to form an active enzyme.
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