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PBR Antibody

Rabbit Polyclonal Antibody

     
  • WB - PBR Antibody ABV10033-30
    Western blot analysis of PBR expression using: Lane 1: Jurkat cell lysate; Lane 2: Recombinant PBR; Lane 3: Rat kidney tissue lysate
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  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P61328
Other Accession BAA04749
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27399 Da
Additional Information
Gene ID 2257
Application & Usage Western blot analysis (0.5-4 µg/ml) and Immunohistochemistry (10-20 µg/ml). However, the optimal conditions should be determined individually.
Other Names peripheral-type benzodiazepine receptor
Target/Specificity PBR
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-PBR polyclonal antibody in phosphate buffered saline (PBS), pH 7.2.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPBR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FGF12
Synonyms FGF12B, FHF1
Function Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.
Cellular Location Nucleus.
Tissue Location Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures
Research Areas
Citations (0)
citation

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Background

PBR (Peripheral-type Benzodiazepine Receptor) is a ubiquitous protein (18 kDa) found in most steroidogenic tissues. It is located primarily in the outer mitochondrial membrane of steroid-producing tissues and is found in association with a 34 kDa voltage-dependent anion channel protein (VDAC). PBR is involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane. It is tho µght to be part of the mitochondrial permeability transition pore (PT) and to be involved in apoptosis.

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Discontinued
Cat# ABV10033-30
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