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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   DFF40 Antibody   

DFF40 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O54788
Other Accession AAH53052
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 39449 Da
Additional Information
Gene ID 13368
Application & Usage Western blotting (0.5-4 µg/ml) and Immunohistochemistry (2-8 µg/ml). However, the optimal conditions should be determined individually. The antibody detects a 43 kDa DFF40/CAD of human, mouse and rat origins. Mouse kidney tissue lysate can be used as a positive control.
Other Names DFFB, CAD, DFF-40 , CPAN , DFF2
Target/Specificity DFF40
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) immunoaffinity purified rabbit DFF40 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsDFF40 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Dffb
Synonyms Cad
Function Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Cellular Location Cytoplasm. Nucleus.
Research Areas
Citations (0)

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DFF is composed of two subunits: DFF40/CAD and DFF45/ICAD. Human DFF45 and its mouse homologue ICAD are the inhibitors of DFF40 and CAD, respectively. Cleavage of DFF45, which is mediated by caspase-3, leads to DFF40’s activation as a nuclease. Activation of DFF40/CAD can lead to DNA fragmentation, a hallmark of apoptosis. DFF40 mRNA is expressed in limited number of human tissues: pancreas, spleen, prostate, and ovary.

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$ 265.00
Cat# ABV10037
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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