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PRMT7 Antibody

Rabbit Polyclonal Antibody

  • WB - PRMT7 Antibody ABV10045
    Western blot analysis of PRMT7 using Jurkat cell lysate (Lane1 & 2)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NVM4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 78459 Da
Additional Information
Gene ID 54496
Positive Control Jurkat cell lysate
Application & Usage The antibody can be used in Western Blot analysis (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately.
Other Names Protein arginine N-methyltransferase 7, PRMT7
Target/Specificity PRMT7
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-PRMT7 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPRMT7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRMT7
Synonyms KIAA1933
Function Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
Cellular Location Cytoplasm, cytosol. Nucleus
Citations (0)

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Arginine methylation is an important protein modification catalyzed by arginine methyltransferase such as PRMT7. PRMT7 has two methyltransferase domains each containing a putative AdoMet binding motif. Arginine methylation has been implicated in signal transduction RNA processing and splicing.

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$ 245.00
Cat# ABV10045
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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