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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD40 Antibody   

CD40 Antibody

Rabbit Polyclonal Antibody

  • WB - CD40 Antibody ABV10052
    Western blot analysis of CD40 expression in rat kidney tissue lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P25942
Reactivity Human, Mouse, Rat, Monkey, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 30619 Da
Additional Information
Gene ID 958
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.
Other Names CDW40, CDw40, p50, Bp50, MGC9013, TNFRSF5
Target/Specificity CD40
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) immunoaffinity purified rabbit anti-CD40 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCD40 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD40
Synonyms TNFRSF5
Function Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Cellular Location Isoform I: Cell membrane; Single-pass type I membrane protein
Tissue Location B-cells and in primary carcinomas.
Research Areas
Citations (0)

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CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L), a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center thro µgh interaction with T cells expressing CD40L, and activation of CD4+ T cells. In non-hemopoitic cells such as epidermal basal cells, CD40 ligation serves as the signal for inhibition of cell growth and induction of differentiation. The cytoplasmic domain of CD40 interacts with TRAF6, a TNFR associated factor homolog that mediates signaling from CD40. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.

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$ 265.00
Cat# ABV10052
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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