|Reactivity||Human, Mouse, Rat, Dog|
|Calculated MW||56849 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml) .However, the optimal conditions should be determined individually. The antibody detects ~58kDa cytochrome P450 IIE1 from samples of human, mouse, rat and dog origins.|
|Other Names||AHH , AHRR, CYP1A1 , CP11 , CYP1, P1-450, CYPIA1, P450-C, , P450DX, P450-P1|
|Formulation||100 µg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Cytochrome P450 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome P450 is mainly found in liver, and can metabolize a wide range of compounds such as organic solvents, acetaminophen, dimethylnitrosoamine and aliphatic alcohol, which have certain toxicological effects in humans. Ethanol-induced cytochrome P450 IIE1 is considered to be one of the major causes of oxidative stress in the liver following ethanol treatment.
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